SBCNY - Systems Biology Center New York

Resources Spotlight

Drug Toxicity Signature Generation Center


The Drug Toxicity Signature Generation Center is a NIH-funded Systems Pharmacology research center at the Icahn School of Medicine. The proteomics experiments for the center are conducted at the Center for Advanced Proteomics, Rutgers-New Jersey Medical School. DToxS is part of the LINCS consortium of centers. LINCS (Library of Integrated Network-Based Cellular Signatures) is a program supported by the NIH Common Fund.

Many Experimental protocols for systems biology research are available here:

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Research Highlights

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening.

Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst JSchlessinger A.
PLoS Comput Biol. 2015 Oct 7;11(10):e1004477.

Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis.

Stockton SD Jr, Gomes I, Liu T, Moraje C, Hipólito L, Jones MR, Ma'ayan A, Morón JA, Li H Devi LA..
Mol Cell Proteomics 2015 Oct;14(10):2564-76.

Can intracellular cAMP dynamics enable scalable computation?

Iyengar R.
Front Cell Neurosci. 2015 Mar 27;9:112.

2016 Seminars and Meetings

  • Tuesday, April 27, 2016 Kathleen M. Giacomini, PhD
    Metabolomic and Genomewide Studies Reveal New Roles for Transporters
    4:00am, Annenberg 19-79
  • Friday, September 30, 2016 Shankar Subramaniam, PhD
    Systems Medicine and Systems Pharmacology
    4:00am, Annenberg 19-79
  • Friday, October 7, 2016 Boris N. Kholodenko, D.Sc.
    Catching signals surfing the net
    11:00am, Annenberg 19-79
  • Monday, October 10, 2016 Bruce J. Aronow, PhD
    Single Cell Transcriptomic Identification of Celltypes and Subtypes During Development: New Recipes for Lineage Differentiation, Organ Morphogenesis and an Unexpectedly Deep Intercellular Interactome
    4:00pm, Annenberg 19-79
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Enrichr

Gene Expression Data Analysis Tool - Enrichr

Enrichr is an integrative web-based and mobile gene-list enrichment analysis tool

Dr. Marc Birtwistle

Gene-list Enrichment Analysis Tool - CHEA

ChEA is a web-based system where users can input lists of mammalian gene symbols for which the program computes over-representation of transcription factor targets from the ChIP-X database.

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New York University
IBM
Pathways Commons
City University of New York