The Drug Toxicity Signature Generation Center is a NIH-funded Systems Pharmacology research center at the Icahn School of Medicine. The proteomics experiments for the center are conducted at the Center for Advanced Proteomics, Rutgers-New Jersey Medical School. DToxS is part of the LINCS consortium of centers. LINCS (Library of Integrated Network-Based Cellular Signatures) is a program supported by the NIH Common Fund.
Many Experimental protocols for systems biology research are available here:
Falkenberg CV, Azeloglu EU, Stothers M, Deerinck TJ, Chen Y, He JC, Ellisman MH, Hone JC, Loew LMIyengar R.
PLoS Comput Biol. 2017 Mar 16;13(3):e1005433
Hu M, Azeloglu EU, Ron A, Tran-Ba KH, Calizo RC, Tavassoly I, Bhattacharya S, Jayaraman G, Chen Y, Rabinovich V, Hone JC, He JC,4, Kaufman LJ.Iyengar R.
Sci Rep. 2017 Mar 6;7:43934.
Marc R. Birtwistle, Jens Hansen, James M. Gallo, Sreeharish Muppirisetty, Peter Man-Un Ung, Ravi Iyengar and Avner Schlessinger
Systems Pharmacology and Pharmacodynamics Chapter 4 (02 December 2016)
Bouhaddou M, DiStefano MS, Riesel EA, Carrasco E, Holzapfel HY, Jones DC, Smith GR, Stern AD, Somani SS, Thompson TV, Birtwistle MR
Nature 2016 Nov 30;540(7631):E9-E10.
Song RS, Tolentino R, Neves-Zaph SR Sobie EA
J Biol Chem. 2016 Oct 28;291(44):23257-23267.
Devenyi RA, Ortega FA, Groenendaal W, Krogh-Madsen T, Christini DJ2, Sobie EA
J Physiol. 2016 Oct 24. doi: 10.1113/JP273191
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