Center Overview

Systems Biology Center New York is a trans-disciplinary center that uses systems approaches to study pathophysiological processes and drug action. We are a highly collaborative group of researchers both basic and clinical, and educators from several universities in the New York area. Center investigators have expertise in genomics, biochemistry and molecular biology, proteomics, in cell biology and visualization of signaling reactions live cells, in tissue/organ physiology and pathophysiology, clinical imaging and in pharmacology. At the computational level we have expertise in statistical models, graph-theory network based analyses, mathematical biology and dynamical modeling including ODE, PDE and stochastic models. Melding the expertise of various disciplines, we work at various scales of biological organization to make substantive contributions to the emerging fields of systems pharmacology and precision medicine. During the next term of this grant, we will use our complementary expertise in a highly integrated manner to develop and disseminate approaches that provide a mechanistic understanding of how molecular interactions within regulatory networks result in tissue and organ behavior and how this information can be used to predict new drug targets, repurpose existing drugs and predict adverse events in the context of genomic and epigenomic characteristics.

Our research activities are seamlessly connected to our education and outreach activities that include working with the faculty at Colgate University to enhance the Systems Biology Program for undergraduates. We are offering three free online Systems Biology courses on Coursera's MOOC platform. We will develop new collaborations with the Systems Biology Ireland and continue and our highly successful undergraduate summer program for The City University of New York (CUNY) students from diverse backgrounds to prime the pipeline for the next generation of quantitative biomedical scientists.

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