Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Source: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
PMID: 16099987 | PMCID: PMC3032439 | EndNote Citation

Index of Nodes

ACTIN


Average path length to all other components: 3.49094
Clustering coefficient: 0.0233918
Grid coefficient: 0.00136452

Swiss-Prot Human Accession Code: P60709
Swiss-Prot Mouse Accession Code: P60711

List of interactions:

Source:PROFILINType of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:+
References:
1. W. Witke, A. V. Podtelejnikov, et al., EMBO. J. 17, 967 (1998). PubMed ID: 9463375
2. S. C. Mockrin, E. D. Korn, Biochemistry. 19, 5359 (1981). PubMed ID: 6893804

Source:SPINOPHILINType of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. S. D. Grossman, M. Futter, G. L. Snyder, et al., J. Neurochem. 90, 317 (2004). PubMed ID: 15228588
2. L. C. Hsieh-Wilson, F. Benfenati, G. L. Snyder, et al., J. Biol. Chem. 278, 1186 (2003). PubMed ID: 12417592
3. A. Satoh, H. Nakanishi, H. Obaishi, et al., J. Biol. Chem. 273, 3470 (1998). PubMed ID: 9452470

Source:RADIXINType of molecule:Adapter Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. R. Vaiskunaite, V. Adarichev, H. Furthmayr, et al., J. Biol. Chem. 275, 26206 (2000). PubMed ID: 10816569

Source:ARP23Type of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:+
References:
1. R. D. Mullins, J. A. Heuser, T. D. Pollard, Proc. Natl. Acad. Sci. U. S. A. 95, 6181 (1998). PubMed ID: 9600938

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:FASCINType of molecule:CellAdhesion Location:Membrane
Type of interaction:Binding Effect:0
References:
1. S. Ono, Y. Yamakita, S. Yamashiro, et al., J. Biol. Chem. 272, 2527 (1997). PubMed ID: 8999969

Source:CORTACTINType of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:+
References:
1. S. A. Weed, A. V. Karginov, D. A. Schafer, et al., J. Cell. Biol. 151, 29 (2000). PubMed ID: 11018051
2. H. Wu, J. T. Parsons, J. Cell. Biol. 120, 1417 (1993). PubMed ID: 7680654

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:MARCKSType of molecule:Adapter Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. J. H. Hartwig, M. Thelen, A. Rosen, et al., Nature. 356, 618 (1992). PubMed ID: 1560845

Source:COFILINType of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:_
References:
1. L. S. Minamide, A. M. Striegl, J. A. Boyle, et al., Nat. Cell. Biol. 2, 628 (2001). PubMed ID: 10980704
2. A. Muhlrad, D. Kudryashov, et al., J. Mol. Biol. 342, 1559 (2004). PubMed ID: 15364581

Source:GELSOLINType of molecule:Cytoskeleton Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. K. Furukawa, W. Fu, Y. Li, et al., J. Neurosci. 17, 8178 (1997). PubMed ID: 9334393

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:N41Type of molecule:Adapter Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. M. Sheng, M. J. Kim, Science. 298, 776 (2002). PubMed ID: 12399578

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:SPECTRINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. G. Subrahmanyam, P. J. Bertics, R. A. Anderson, Proc. Natl. Acad. Sci. U. S. A. 88, 5222 (1991). PubMed ID: 1647028

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:IQGAPType of molecule:GAP Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. S. C. Mateer, A. E. McDaniel, V. Nicolas, et al., J. Biol. Chem. 277, 12324 (2002). PubMed ID: 11809768
2. A. M. Bashour, A. T. Fullerton, M. J. Hart, et al., J. Cell. Biol. 137, 1555 (1997). PubMed ID: 9199170

Source:SYNAPSINType of molecule:Vesicle Location:Vesicles
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:+
References:
1. R. Goold, K. M. Chan, A. J. Baines, Biochemistry. 34, 1912 (1995). PubMed ID: 7849051

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:ALPHAACTININType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. E. Lazarides, J. Cell. Biol. 68, 202 (1976). PubMed ID: 1107334

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:FILAMINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. K. Wang, S. J. Singer, Proc. Natl. Acad. Sci. U. S. A. 74, 2021 (1977). PubMed ID: 325564

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:NEURABINType of molecule:Adapter Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. H. Nakanishi, H. Obaishi, A. Satoh, et al., J. Cell. Biol. 139, 951 (1997). PubMed ID: 9362513

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:VINCULINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. B. M. Jockusch, G. Isenberg, Proc. Natl. Acad. Sci. U. S. A. 78, 3005 (1981). PubMed ID: 6789327

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:TALINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. M. Muguruma, S. Matsumura, T. Fukazawa, Biochem. Biophys. Res. Commun. 171, 1217 (1990). PubMed ID: 2121138

Source:PKCEType of molecule:Kinase Location:Cytosol
Target:ACTINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. R. Prekeris, R. M. Hernandez, M. W. Mayhew, et al., J. Biol. Chem. 273, 26790 (1998). PubMed ID: 9756923