Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Source: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
PMID: 16099987 | PMCID: PMC3032439 | EndNote Citation

Index of Nodes

FILAMIN


Average path length to all other components: 3.76606
Clustering coefficient: 0
Grid coefficient: 0.0294118

Swiss-Prot Human Accession Code: P21333
Swiss-Prot Mouse Accession Code: Q8BTM8

List of interactions:

Source:PKAType of molecule:Kinase Location:Cytosol
Target:FILAMINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Phosphorylation Effect:+
References:
1. D. Jay, E. J. Garcia, l. a. de, et al., Mol. Cell. Biochem. 260, 49 (2004). PubMed ID: 15228085
2. D. Wallach, P. J. Davies, I. Pastan, J. Biol. Chem. 253, 4739 (1978). PubMed ID: 207708

Source:ACTINType of molecule:Cytoskeleton Location:Cytosol
Target:FILAMINType of molecule:Cytoskeleton Location:Cytosol
Type of interaction:Binding Effect:0
References:
1. K. Wang, S. J. Singer, Proc. Natl. Acad. Sci. U. S. A. 74, 2021 (1977). PubMed ID: 325564