Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Source: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
PMID: 16099987 | PMCID: PMC3032439 | EndNote Citation

Index of Nodes

PKR


Average path length to all other components: 4.41186
Clustering coefficient: 0.166667
Grid coefficient: 0.0324074

Swiss-Prot Human Accession Code: Q8TCW9
Swiss-Prot Mouse Accession Code: Q9JKL1

List of interactions:

Source:PKRType of molecule:Kinase Location:Cytosol
Target:EIF2Type of molecule:Ribosome Location:Ribosomes
Type of interaction:Phosphorylation Effect:_
References:
1. J. Galabru, A. Hovanessian, J. Biol. Chem. 262, 15538 (1987). PubMed ID: 3479429
2. Z. Xu, B. R. Williams, Mol. Cell. Biol. 20, 5285 (2000). PubMed ID: 10866685
3. C. R. Prostko, J. N. Dholakia, M. A. Brostrom, et al., J. Biol. Chem. 270, 6211 (1995). PubMed ID: 7890757
4. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID: 11555640

Source:CASPASE8Type of molecule:Protease Location:Cytosol
Target:PKRType of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID: 11555640

Source:CASPASE3Type of molecule:Protease Location:Cytosol
Target:PKRType of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID: 11555640

Source:CASPASE7Type of molecule:Protease Location:Cytosol
Target:PKRType of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID: 11555640