Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells
Source: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R.
Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
PMID: 16099987 | PMCID: PMC3032439 | EndNote Citation
Index of Nodes
PKR
Average path length to all other components: 4.41186
Clustering coefficient: 0.166667
Grid coefficient: 0.0324074
Swiss-Prot Human Accession Code: Q8TCW9
Swiss-Prot Mouse Accession Code: Q9JKL1
List of interactions:
Source:PKR Type of molecule:Kinase Location:Cytosol
Target:EIF2 Type of molecule:Ribosome Location:Ribosomes
Type of interaction:Phosphorylation Effect:_
References:
1. J. Galabru, A. Hovanessian, J. Biol. Chem. 262, 15538 (1987). PubMed ID:
3479429
2. Z. Xu, B. R. Williams, Mol. Cell. Biol. 20, 5285 (2000). PubMed ID:
10866685
3. C. R. Prostko, J. N. Dholakia, M. A. Brostrom, et al., J. Biol. Chem. 270, 6211 (1995). PubMed ID:
7890757
4. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID:
11555640
Source:CASPASE8 Type of molecule:Protease Location:Cytosol
Target:PKR Type of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID:
11555640
Source:CASPASE3 Type of molecule:Protease Location:Cytosol
Target:PKR Type of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID:
11555640
Source:CASPASE7 Type of molecule:Protease Location:Cytosol
Target:PKR Type of molecule:Kinase Location:Cytosol
Type of interaction:Cleavage Effect:_
References:
1. X. Saelens, M. Kalai, P. Vandenabeele, J. Biol. Chem. 276, 41620 (2001). PubMed ID:
11555640
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