Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Source: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
PMID: 16099987 | PMCID: PMC3032439 | EndNote Citation

Index of Nodes

PMCA


Average path length to all other components: 3.1944
Clustering coefficient: 0.133333
Grid coefficient: 0.0215589

Swiss-Prot Human Accession Code: P20020
Swiss-Prot Mouse Accession Code: Q9R0K7

List of interactions:

Source:PIP2Type of molecule:Lipid Location:Cytosol
Target:PMCAType of molecule:Pump Location:Membrane
Type of interaction:Binding Effect:+
References:
1. D. W. Hilgemann, S. Feng, C. Nasuhoglu, Sci. STKE. 2001, RE19, (2001). PubMed ID: 11734659
2. V. Niggli, E. S. Adunyah, E. Carafoli, J. Biol. Chem. 256, 8588 (1981). PubMed ID: 6455424

Source:PMCAType of molecule:Pump Location:Membrane
Target:CALCIUMType of molecule:Messenger Location:Cytosol
Type of interaction:Pumping Effect:_
References:
1. V. Niggli, E. S. Adunyah, E. Carafoli, J. Biol. Chem. 256, 8588 (1981). PubMed ID: 6455424

Source:CALMODULINType of molecule:Activator Location:Cytosol
Target:PMCAType of molecule:Pump Location:Membrane
Type of interaction:Binding Effect:+
References:
1. V. Niggli, E. S. Adunyah, E. Carafoli, J. Biol. Chem. 256, 8588 (1981). PubMed ID: 6455424

Source:CASKType of molecule:Kinase Location:Cytosol
Target:PMCAType of molecule:Pump Location:Membrane
Type of interaction:Binding Effect:+
References:
1. K. Schuh, S. Uldrijan, S. Gambaryan, et al., J. Biol. Chem. 278, 9778 (2003). PubMed ID: 12511555

Source:PKCType of molecule:Kinase Location:Cytosol
Target:PMCAType of molecule:Pump Location:Membrane
Type of interaction:Phosphorylation Effect:_
References:
1. Y. M. Usachev, S. J. DeMarco, C. Campbell, et al., Neuron. 33, 113 (2002). PubMed ID: 11779484
2. L. Zylinska, D. Guerini, E. Gromadzinska, et al., Biochim. Biophys. Acta. 1448, 99 (1999). PubMed ID: 9824678

Source:PKAType of molecule:Kinase Location:Cytosol
Target:PMCAType of molecule:Pump Location:Membrane
Type of interaction:Phosphorylation Effect:_
References:
1. L. Zylinska, D. Guerini, E. Gromadzinska, et al., Biochim. Biophys. Acta. 1448, 99 (1999). PubMed ID: 9824678