Emergent Properties of Networks of Biological Signaling Pathways
Simulation Details for Figures in the Paper
Source: Science. 1999 Jan;283(5400):381-7.
Downloading demonstration scripts
This set of demonstration programs replicates most of the figures of the paper. The instructions for downloading the demonstration programs are in the readme file. The demonstrations use the Caltech Neuronal simulator GENESIS, which runs on most UNIX machines, with the architectures given below. You can also download the entire demonstration directory in gzip (6.1 MB) or regular (9.1 MB) compressed format. The demonstration directory includes binaries for the following architectures:
- Linux on Intel machines
- Linux on Alpha microprocessors
- Solaris
- Sun OS
- IRIX
Compartmental model of CA1 neuron as used for generating Ca waveforms used for stimuli in Figure 3A. These Ca transients were computed for a series of 3 tetanic stimuli at 100 Hz, lasting 1 second each, separated by 10 minutes.
This simulation was carried out on GENESIS 2.0.2 and is not compatible with the more recent versions of GENESIS. The Linux binaries for GENESIS 2.0.2 and the complete scripts for running the simulation have been tar-ed and compressed in gzip format (600K) and regular compressed format (900K) for downloading.
Simulated Ca influx (uM): Details of time-course
Simulated Ca influx (uM): One tetanic stimulus
Simulated Ca influx (uM): Complete stimulus
